Thông tư 52/2025/TT-BYT về Danh mục bệnh truyền nhiễm, đối tượng và phạm vi phải sử dụng vắc xin, sinh phẩm y tế bắt buộc do Bộ trưởng Bộ Y tế ban hành

CIRCULAR

ON PROMULGATION OF THE LIST OF INFECTIOUS DISEASES, RECIPIENTS AND SCOPE OF COMPULSORY VACCINATION AND BIOLOGICAL PRODUCTS

Pursuant to the Law on Prevention and Control of Infectious Diseases No. 03/2007/QH12;

Pursuant to Decree No. 42/2025/ND-CP dated February 27, 2025 of the Government on functions, tasks, powers and organizational structure of the Ministry of Health of Vietnam;

At the request of the Director General of the Vietnam Administration of Disease Prevention;

The Minister of Health promulgates the Circular on promulgation of the List of infectious diseases, recipients and scope of compulsory vaccination and biological products.

Article 1. List of infectious diseases and recipients, age and schedule for vaccination under the Expanded Program on Immunization

No.

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Vaccines, recipients, age and schedule for vaccination under the Expanded Program on Immunization

Vaccines

Recipients

Age and schedule for vaccination

1

Hepatitis (compulsory for Hepatitis B)

Single-antigen hepatitis B vaccines

Newborns

- Birth dose: Within first 24 hours after birth.

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Hepatitis B combination vaccines

Infants

- First dose: Infants at 2 months of age.

- Second dose: At least 1 month (*) after the first dose.

- Third dose: At least 1 month after the second dose.

- In cases where the vaccination does not follow the prescribed schedule, the following schedule shall apply:

+ For infants under 12 months of age

First dose: as soon as possible.

Second dose: At least 1 month after the first dose.

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+ For infants from 12 months of age

First dose: as soon as possible.

Second dose: At least 1 month after the first dose.

Third dose: At least 6 month after the second dose.

2

Tuberculosis

Tuberculosis vaccines

Infants

- Single injection within 1 month after birth.

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3

Diphtheria

Diphtheria combination vaccines

Infants

- First dose: Infants at 2 months of age.

- Second dose: At least 1 month after the first dose.

- Third dose: At least 1 month after the second dose.

- In cases where the vaccination does not follow the prescribed schedule, the following schedule shall apply:

+ For infants under 12 months of age

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Second dose: At least 1 month after the first dose.

Third dose: At least 1 month after the second dose.

+ For infants from 12 months of age

First dose: as soon as possible.

Second dose: At least 1 month after the first dose.

Third dose: At least 6 month after the second dose.

Infants

- First repeated dose for infants at 18 months of age

- If the first repeated dose does not follow the prescribed schedule, the first repeated dose for infants from 18 months of age shall be given at least 6 months after the third dose and before full 4 years old.

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Children

- Second repeated dose for children at 7 years old.

- If the second repeated dose does not follow the prescribed schedule, the second repeated dose for children from 7 years old shall be given at least 4 years after the first repeated dose.

4

Whooping-cough

Whooping-cough combination vaccines

Infants

- First dose: Infants at 2 months of age.

- Second dose: At least 1 month after the first dose.

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- In cases where the vaccination does not follow the prescribed schedule:

+ For infants under 12 months of age

First dose: as soon as possible.

Second dose: At least 1 month after the first dose.

Third dose: At least 1 month after the second dose.

+ For infants from 12 months of age

First dose: as soon as possible.

Second dose: At least 1 month after the first dose.

Third dose: At least 6 month after the second dose.

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- Repeated dose for infants at 18 months of age.

- If the repeated dose does not follow the prescribed schedule, the repeated dose for infants from 18 months of age shall be given at least 6 months after the third dose and before full 4 years old.

5

Tetanus

Tetanus combination vaccines

Infants

- First dose: Infants at 2 months of age.

- Second dose: At least 1 month after the first dose.

- Third dose: At least 1 month after the second dose.

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+ For infants under 12 months of age

First dose: as soon as possible.

Second dose: At least 1 month after the first dose.

Third dose: At least 1 month after the second dose.

+ For infants from 12 months of age

First dose: as soon as possible.

Second dose: At least 1 month after the first dose.

Third dose: At least 6 month after the second dose.

Infants

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- If the first repeated dose does not follow the prescribed schedule, the first repeated dose for infants from 18 months of age shall be given at least 6 months after the third dose and before full 4 years old.

Children

- Second repeated dose for children at 7 years old.

- If the second repeated dose does not follow the prescribed schedule, the second repeated dose for children from 7 years old shall be given at least 4 years after the first repeated dose.

Tetanus vaccines for pregnant women

Pregnant women

1. Those who have not been vaccinated or have not yet received 3 injections of vaccines containing standard-dose tetanus vaccine antigens (given before 1 year of age) or have unclear history of vaccination:

- First dose: Early injection during pregnancy.

- Second dose: At least 1 month after the first dose.

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- Fourth dose: During the next pregnancy and at least 1 year after the third dose.

- Fifth dose: During the next pregnancy and at least 1 year after the fourth dose.

2. Those who have been given 3 injections of vaccines containing standard-dose tetanus vaccine antigens:

- First dose: Early injection during pregnancy.

- Second dose: At least 1 month after the first dose.

- Third dose: During the next pregnancy and at least 1 year after the second dose.

3. Those who have been given 3 injections of vaccines containing standard-dose tetanus vaccine antigens and 1 repeated dose injection:

- First dose: Early injection during pregnancy.

- Second dose: During the next pregnancy and at least 1 year after the first dose.

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In all cases, the last dose must be injected at least 2 weeks before the expected date of birth.

6

Polio

Multiple-antigen orally administered polio vaccines

Infants

- First dose: Infants at 2 months of age.

- Second dose: At least 1 month after the first dose.

- Third dose: At least 1 month after the second dose.

- In cases where the vaccination does not follow the prescribed schedule:

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Second dose: At least 1 month after the first dose.

Third dose: At least 1 month after the second dose.

Multiple-antigen injection administered polio vaccines

Infants

- First dose: Infants at 5 months of age.

- Second dose: Infants at 9 months of age.

- In cases where the vaccination does not follow the prescribed schedule, the following schedule shall apply: First dose: as soon as possible.

Second dose: injection when infants are from 9 months of age and at least 1 month after the first dose.

7

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Single-antigen Haemophilus influenzae type b vaccines or Haemophilus influenzae type b combination vaccines

Infants

- First dose: Infants at 2 months of age.

- Second dose: At least 1 month after the first dose.

- Third dose: At least 1 month after the second dose.

- In cases where the vaccination does not follow the prescribed schedule, the following schedule shall apply:

+ For infants under 12 months of age

First dose: as soon as possible.

Second dose: At least 1 month after the first dose.

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+ For infants from 12 to under 18 months of age:

First dose: as soon as possible.

Second dose: At least 1 month after the first dose.

Third dose: At least 6 month after the second dose.

+ For infants from 18 months of age: First injection as soon as possible and before full 5 years old

8

Measles

Single-antigen measles vaccines

Infants

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- In cases where the vaccination does not follow the prescribed schedule, infants shall be vaccinated as soon as possible.

Measles combination vaccines

Infants

- Repeated dose for infants at 18 months of age.

- If the repeated dose does not follow the prescribed schedule, the repeated dose for infants from 18 months of age shall be given at least 1 month after the last Measles combination vaccine is given.

9

Rubella

Rubella combination vaccines

Infants

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- In cases where the vaccination does not follow the prescribed schedule, infants shall be vaccinated as soon as possible when they are from 18 months of age.

10

Viral Encephalitis (compulsory for Japanese Encephalitis)

Japanese Encephalitis vaccines

Infants

- First dose: Infants at 1 year old..

- Second dose: At least 1 -2 weeks after the first dose.

- Third dose: At least 1 year after the first dose.

- In cases where the vaccination does not follow the prescribed schedule, the following schedule shall apply:

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+ Second dose: At least 1 -2 weeks after the first dose.

+ Third dose: at least 1 year after the first dose and 1 month after the second dose.

11

Rotavirus

Infants

- First dose: Infants at 2 months of age.

- Second dose: At least 1 month after the first dose.

- In cases where the vaccination does not follow the prescribed schedule, the following schedule shall apply: First dose: as soon as possible when infants are from 2 months of age.

Second dose: at least 1 month after the first dose and before full 6 years old.

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Pneumococcal disease

Pneumococcal vaccine

Infants

- First dose: Infants at 2 months of age.

- Second dose: At least 2 month after the first dose.

- In cases where the vaccination does not follow the prescribed schedule, the following schedule shall apply:

+ For infants under 12 months of age

First dose: as soon as possible.

Second dose: At least 2 month after the first dose.

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First dose: as soon as possible.

Second dose: At least 2 month after the first dose.

+ For those from 24 months of age that have not received Pneumococcal vaccine, they shall receive 1 dose as soon as possible and before full 5 years old.

(*) At least 28 days apart.

Article 2. List of infectious diseases, recipients of compulsory vaccination and biological products who are susceptible to infectious diseases in or from affected areas

1. The List of infectious diseases, recipients of compulsory vaccination and biological products who are susceptible to infectious diseases in or from affected areas:

No.

Infectious diseases

Vaccines and biological products

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Diphtheria

Diphtheria combination vaccines, diphtheria antitoxin

2

Polio

Multiple-antigen polio vaccines or multiple-antigen polio combination vaccines

3

Whooping-cough

Whooping-cough combination vaccines

4

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Rubella combination vaccines

5

Measles

Single-antigen measles vaccines or measles combination vaccines

6

Cholera

Cholera vaccines

7

Viral Encephalitis (compulsory for Japanese Encephalitis)

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8

Rabies

Rabies vaccines, rabies antitoxin

9

Influenza

Influenza vaccines

10

COVID-19

COVID-19 vaccines

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Article 3. Scope of compulsory vaccination and biological products

1. Compulsory vaccination prescribed in the List in Article 1 of this Circular shall be provided nationwide for children and pregnant women in the Expanded Program on Immunization, except for Pneumococcal vaccine prescribed in clause 2 of this Article.

2. The use of Pneumococcal vaccine shall comply with Resolution No. 104/NQ-CP dated August 15, 2022 of the Government on the roadmap for increase in quantity of vaccines in the Expanded Program on Immunization for 2021 – 2030 period.

3. The use of compulsory vaccination and biological products as prescribed in the List in clause 1, Article 2 of this Circular shall comply with decisions of People's Committees of provinces/cities, and guidelines of the Ministry of Health based on epidemic situations.

Article 4. Effect

1. This Circular comes into force from February 15, 2026.

2. Circular No. 10/2024/TT-BYT dated June 13, 2024 of the Minister of Health on promulgation of the list of infectious diseases, recipients and scope of compulsory vaccination and biological products ceases to be effective from the effective date of this Circular.

Article 5. Reference clause

In cases where the documents cited in this Circular are replaced, amended or supplemented, the newer documents shall prevail.

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Director General of the Vietnam Administration of Disease Prevention; heads of units affiliated to the Ministry of Health; relevant organizations and individuals are responsible for implementing this Circular.

Authorities, organizations and individuals shall report any issues arise during the implementation to the Ministry of Health (Vietnam Administration of Disease Prevention) for consideration and resolution./.

PP. MINISTER
DEPUTY MINISTER




Nguyen Thi Lien Huong